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Vodka vs Tequila

Both are among the cleaner mainstream spirits. Vodka wins on pure chemistry — multiple distillations and aggressive filtration leave nearly nothing but ethanol. 100% agave tequila is close, with the advantage of more flavor and no need for sugary mixers to be palatable.

Vodka

Closest to neutral alcohol you can drink

Hangover Index
2/10
Light
Chemistry
Congeners
Very Low
Histamines
Very Low
Polyphenols
Very Low
Sulfites
Very Low
Tannins
Very Low
Sugar
Very Low
Additives
Low

Tequila

Agave, regulated, sometimes adulterated

Hangover Index
4/10
Moderate
Chemistry
Congeners
Low
Histamines
Low
Polyphenols
Low
Sulfites
Very Low
Tannins
Low
Sugar
Low
Additives
Moderate
Verdict

On a pure chemistry-load basis, vodka edges out tequila. In practice — accounting for how people actually drink them — 100% agave tequila neat or on the rocks beats vodka cut with sugary mixers.

Which one for which situation

You drink it neat or with soda water
→ Either works
Both score 2–4 on Hangover Index unflavored.
You need gluten-free
→ Tequila
All 100% agave tequila is naturally gluten-free. Most vodka is too, but corn-based brands (Tito's) are safer for severe sensitivity.
You want the fewest additives
→ Vodka
Unflavored vodka has none. 100% agave tequila allows up to 1% additives — most do use them.
You want flavor without sugar
→ Tequila
Blanco tequila delivers character; unflavored vodka tastes like nothing on purpose.

FAQ

Is tequila healthier than vodka?

On chemistry alone, no — vodka is cleaner. But tequila is close enough that lifestyle factors (mixers, serving size) matter more. 100% agave tequila neat is in the same low-load tier as vodka.

Which has fewer calories, vodka or tequila?

Effectively identical. Both run about 96 calories per 1.5oz at 40% ABV. Calorie differences between spirits at the same ABV are negligible.

Does tequila have less of a hangover than vodka?

Vodka generally produces the mildest hangover of any common spirit. Blanco tequila is close. Cheap mixto tequila with additives is noticeably worse than vodka.